Susceptibility of Chlamydia trachomatis to the excipient hydroxyethyl cellulose: pH and concentration dependence of antimicrobial activity.
نویسندگان
چکیده
Hydroxyethyl cellulose (HEC) is used as a neutral excipient in microbicides used against sexually transmitted pathogens. However, HEC inhibits the infection of cervical epithelial cells by Chlamydia trachomatis at pH 5 in a concentration-dependent manner. At pH 7, infection is inversely dependent on the concentration of HEC, possibly due to pH-dependent calcium sequestration.
منابع مشابه
Susceptibility of Chlamydia trachomatis to excipients commonly used in topical microbicide formulations.
Commonly used "inactive" pharmaceutical excipients were tested in a previously developed minimum cidal concentration assay to assess their ability to kill Chlamydia trachomatis topically. Sixteen excipients were evaluated in these studies under various conditions. A range of activities was found among the excipients that could be tested in our assay system.
متن کاملIn vitro drug susceptibility of Chlamydia sp. strain TWAR.
The in vitro susceptibilities of eight Chlamydia sp. strain TWAR isolates were tested against tetracycline, erythromycin, penicillin, ampicillin, sulfisoxazole, and a new drug, trospectomycin. The ranges of inhibitory concentrations of these antimicrobial agents, except for sulfonamide, were similar to those for Chlamydia trachomatis. Sulfisoxazole was not inhibitory at the highest nontoxic con...
متن کاملP-41: Association Study of MICA*008 Gene Polymorphism with Chlamydia Trachomatis Infection in Infertile Men Reffer to Royan Institute
Background: Chlamydia trachomatis(CT) is an obligate intracellular bacteria, requires living cells to replicate itself. CT infection can remain up to 4 years in the couple and affect their fertility. The relationship between CT and infertility is very important because most patients are asymptomatic and untreated. After infection with CT, NK activation signals begin through interactions of its ...
متن کاملIn vitro activities of thirteen beta-lactam antibiotics against Chlamydia trachomatis.
The in vitro activity (minimal inhibitory concentration and minimal lethal concentration) of 13 beta-lactam antibiotics against two laboratory strains of Chlamydia trachomatis was compared. No useful activity could be detected.
متن کاملEffect of a cellulose acetate phthalate topical cream on vaginal transmission of simian immunodeficiency virus in rhesus monkeys.
Human immunodeficiency virus type 1 (HIV-1) infection continues to spread in developing countries, mostly through heterosexual transmission. The development of a safe and cost-effective topical microbicide, effective against a range of STDs including HIV-1, would greatly impact the ongoing epidemic. When formulated in a vehicle, a micronized form of cellulose acetate phthalate (CAP), which is a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 52 7 شماره
صفحات -
تاریخ انتشار 2008